| Expression pattern: |
DN |
| Associated gene: |
IGF2BP3, MYC mRNA, METTL3 |
| Associated microRNA: |
- |
| Biological function: |
Enhances ESCC radiosensitivity; circCREBBP knockdown enhances radioresistance, suppresses apoptosis, increases tumor growth after irradiation, and overexpression suppresses survival and increases apoptosis in radioresistant ESCC cells. |
| Molecular mechanism: |
m6A-modified circCREBBP competitively binds IGF2BP3, reducing IGF2BP3 association with MYC mRNA and decreasing MYC mRNA stability. |
| Biological pathway or process: |
radioresistance (inhibits); apoptosis (promotes); mRNA stability (inhibits); m6A modification (other); proliferation (inhibits); drug resistance (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; MeRIP / MeRIP-seq; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
CircCREBBP presents a promising diagnostic and therapeutic target for optimizing patient selection and enhancing radiosensitivity in concurrent chemoradiotherapy. |
| Description: |
circCREBBP is a human CREBBP-derived circRNA that is downregulated in ESCC radioresistant tissues and cells. It enhances radiosensitivity by m6A-dependent competitive binding to IGF2BP3, thereby reducing IGF2BP3-mediated MYC mRNA stability. Functionally, circCREBBP knockdown promotes radioresistance and tumor growth after irradiation, whereas overexpression suppresses survival and increases apoptosis in ESCC cells. |
| Confidence score: |
0.8617 |