| Expression pattern: |
UP |
| Associated gene: |
MUC1, hTERT |
| Associated microRNA: |
miR-145, miR-1182 |
| Biological function: |
Promotes ovarian cancer cell proliferation, migration and invasion, inhibits apoptosis, and promotes peritoneal dissemination via exosomal transfer to peritoneal mesothelial cells. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-145 and miR-1182 to up-regulate downstream targets MUC1 and hTERT (ceRNA mechanism); exosomal circWHSC1 transfer affects peritoneal mesothelium. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circWHSC1 expression was higher in moderate & poor differentiation ovarian cancer tissues than in well differentiation ovarian cancer tissues; positively correlated with differentiation. |
| Description: |
circWHSC1 (hsa_circ_0001387), derived from WHSC1, is up-regulated in epithelial ovarian carcinoma and promotes proliferation, migration/invasion while inhibiting apoptosis. It functions as a ceRNA by sponging miR-145 and miR-1182 to increase MUC1 and hTERT expression, and can be secreted in exosomes to enhance peritoneal dissemination via effects on peritoneal mesothelial cells. |
| Confidence score: |
0.7302 |