circRNA basic information
circBase ID: hsa_circ_0105136
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: CCNB1
Associated microRNA: hsa-miR-548c
Biological function: influenced BC progression
Molecular mechanism: ceRNA network via the miR-548c/CCNB1 axis
Biological pathway or process:

ceRNA regulation (other); proliferation (other); invasion (other)
Detected method:
M
Validation methods:

Bioinformatics Analysis; Microarray
Clinical significance:

these ceRNA axes could be considered biomarkers for BC; correlated with the poor prognosis of BC
Description:

This circRNA was identified from GEO circRNA microarrays and incorporated into a survival-associated ceRNA network in breast cancer. The study proposes a circRNA/miRNA/mRNA axis involving hsa-miR-548c and CCNB1 that may relate to BC progression and prognosis, but the circRNA itself was not experimentally validated.
Confidence score:

0.1768
Other information
Title:

Construction and analysis of a survival-associated competing endogenous RNA network in breast cancer.

Journal: Frontiers in surgery
Published: 2022
PubMed ID: 36684328
Study type:

bioinformatics study
Data availability: GSE101123; GSE101124; GSE97811; TCGA_BRCA
Code availability: -