| Expression pattern: |
UP |
| Associated gene: |
AGO2 |
| Associated microRNA: |
miR-338-5p |
| Biological function: |
promotes HCC cell proliferation, migration and invasion, and promotes mouse tumour growth |
| Molecular mechanism: |
acts as a miR-338-5p sponge and downregulates miR-338-5p |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
High circ0093335 expression was linked with the tumour-node-metastasis stage and microvascular tumour invasion. |
| Description: |
circ0093335 is up-regulated in hepatocellular carcinoma tissues and cell lines and promotes tumor growth and aggressive phenotypes. It mainly localizes in the cytoplasm and accelerates HCC progression by sponging miR-338-5p. |
| Confidence score: |
0.8228 |