circRNA basic information
circBase ID: hsa_circ_0003998
Name: hsa_circ_ARFGEF2
Synonym: -
Host Gene: ARFGEF2
Genomic location(hg19): chr20:47570092-47580435:+
Genomic location(hg38): chr20:48953555-48963898:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent noncancerous tissues; plasma
Cell lines:

HepG2; HuH7; MHCC97H; PLC/PRF/5; L02
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AFP
Associated microRNA: miR-1184, miR-1243, miR-136, miR-145, miR-197, miR-326, miR-330-5p, miR-513a-5p, miR-576-3p, miR-636
Biological function: unknown
Molecular mechanism: Potential miRNA sponge (predicted by Circular RNA Interactome); mechanism not experimentally validated in this study.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

Diagnostic biomarker (ROC AUC=0.894 for HCC vs adjacent noncancerous tissues; plasma level higher in HCC and reduced after operation); prognostic biomarker (high expression associated with poor OS; independent prognostic factor).
Description:

hsa_circ_0003998 is up-regulated in HCC tissues, HCC cell lines, and patient plasma, and decreases after surgery, supporting its diagnostic utility. High hsa_circ_0003998 expression correlates with worse overall survival and is an independent prognostic factor for HCC. Mechanistically, the study provides bioinformatic predictions that it may act as a miRNA sponge, but no functional/axis validation was performed.
Confidence score:

0.6663
Other information
Title:

Hsa_circ_0003998 may be used as a new biomarker for the diagnosis and prognosis of hepatocellular carcinoma.

Journal: OncoTargets and therapy
Published: 2019
PubMed ID: 31410028
Study type:

combined biological and clinical study
Data availability: -
Code availability: -