| Expression pattern: |
DN |
| Associated gene: |
LHPP, Ago2 |
| Associated microRNA: |
miR-346 |
| Biological function: |
Suppresses prostate cancer cell proliferation, invasion, metastasis-related behavior and EMT progression. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-346 to relieve miR-346-mediated repression of LHPP; involves Ago2/RISC binding. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); EMT (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Colony Formation Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; IF (Immunofluorescence); Western Blot |
| Clinical significance: |
circDDX17 may be a potential therapeutic or diagnostic target for prostate cancer. |
| Description: |
circDDX17 is down-regulated in prostate cancer tissues and functions as a tumor suppressor. It inhibits proliferation, invasion and EMT by sponging miR-346 and thereby increasing LHPP expression (circDDX17/miR-346/LHPP axis). |
| Confidence score: |
0.7289 |