circRNA basic information
circBase ID: -
Name: -
Synonym: CCAV
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues; fresh CRC pathological sections
Cell lines:

293T; SW480
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: -
Biological pathway or process:

immune regulation (other); other pathway/process (other)
Detected method:
Q
H
S
Validation methods:

RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; ISH (In Situ Hybridization); RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

CCAV expression was significantly higher in tumor tissues compared to adjacent tissues.
Description:

This study discovered a novel viroid-like circular RNA, CCAV, in colorectal cancer and validated that CCAV is significantly up-regulated in tumor tissues versus adjacent tissues in a 100-patient cohort. Overexpression of CCAV in SW480 cells followed by transcriptome sequencing suggested downstream transcriptomic changes enriched in viral infection, immune-related diseases, and tumor-associated categories, but a specific mechanism was not established.
Confidence score:

0.6362
Other information
Title:

Discovery of a novel viroid-like circular RNA in colorectal cancer.

Journal: Cancer communications (London, England)
Published: 2025
PubMed ID: 39520719
Study type:

combined biological and clinical study
Data availability: PRJNA675665; PRJNA1005762; GenBank: OR538373
Code availability: -