| Expression pattern: |
UP |
| Associated gene: |
LBH, TNF-alpha, NF-kappaB signaling pathway, FUS, AGO2 |
| Associated microRNA: |
hsa-miR-128-3p |
| Biological function: |
promotes malignant phenotype and stemness of GSCs, including cell viability/proliferation, invasion, self-renewal and tumorigenesis |
| Molecular mechanism: |
circZEB1 acts as a ceRNA sponge for miR-128-3p to upregulate LBH; LBH increases TNF-alpha transcription and activates NF-kappaB signaling; LBH upregulates FUS, which binds circZEB1 and maintains its stability, forming a positive feedback loop |
| Biological pathway or process: |
NF-kappaB (promotes); proliferation (promotes); invasion (promotes); stemness (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Sanger Sequencing; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Actinomycin D / DRB Stability Assay; Transfection; MTT; EdU Staining; Transwell Assay; Western Blot; ELISA; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High circZEB1 expression correlates with higher tumor grade and shorter survival; proposed as a biomarker/target for GBM therapy |
| Description: |
circZEB1 is up-regulated in GBM and GSCs and promotes proliferation, invasion, stemness, and in vivo tumorigenesis. It functions as a miR-128-3p sponge to increase LBH, which enhances TNF-alpha and activates NF-kappaB signaling; LBH also increases FUS, and FUS binds circZEB1 to stabilize it, forming a positive feedback loop. |
| Confidence score: |
0.8871 |