circRNA basic information
circBase ID: hsa_circ_0004058
Name: hsa_circ_ZNF292
Synonym: circZNF292
Host Gene: ZNF292
Genomic location(hg19): chr6:87925620-87928449:+
Genomic location(hg38): chr6:87215902-87218731:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004847
MONDO name: senile cataract
Disease details: age-related cataract
Disease DO ID:
 9669
Disease MeSH ID:
 -
Disease NCIt ID:
 C35012
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

anterior lens capsules; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: GPX3, SIRT1, PRDX6, ALDH6A1, SOD1
Associated microRNA: miR-23b-3p
Biological function: Resists oxidative damage and reduces oxidative stress-induced apoptosis in lens epithelial cells (antioxidant role) in ARC.
Molecular mechanism: ceRNA mechanism: circZNF292 sponges miR-23b-3p (AGO-associated), relieving repression of antioxidative target genes (e.g., GPX3, SIRT1, PRDX6, ALDH6A1, SOD1).
Biological pathway or process:

apoptosis (inhibits); oxidative phosphorylation (other); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

Potential biomarker/target for ARC prevention and treatment; plasma circZNF292 is dramatically down-regulated in ARC patients.
Description:

circZNF292 is down-regulated in ARC lens anterior capsule (and also in plasma) and acts as an antioxidant-related circRNA. It functions as a ceRNA by sponging miR-23b-3p, thereby de-repressing anti-oxidative genes (e.g., GPX3, SIRT1, PRDX6, ALDH6A1, SOD1) and potentially reducing oxidative stress-induced apoptosis of lens epithelial cells.
Confidence score:

0.5135
Other information
Title:

Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p.

Journal: Aging
Published: 2020
PubMed ID: 32913142
Study type:

combined biological and clinical study
Data availability: -
Code availability: -