| Expression pattern: |
UP |
| Associated gene: |
GSK3beta, ANAPC7 |
| Associated microRNA: |
miR-640 |
| Biological function: |
circ_0005785 promotes HCC cell viability, proliferation, invasion, migration, angiogenesis and tumor growth, inhibits apoptosis, and reduces paclitaxel sensitivity; circ_0005785 knockdown enhances the antitumor effects of paclitaxel in vitro and in vivo. |
| Molecular mechanism: |
circ_0005785 acts as a ceRNA sponge for miR-640 to regulate GSK3beta expression in PTX-treated HCC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (other); drug resistance (promotes); chemoresistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Tube Formation Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
promising therapeutic target for HCC treatment and preclinical basis for paclitaxel-based chemotherapy |
| Description: |
circ_0005785 is up-regulated in HCC tissues and cell lines and is reduced by paclitaxel treatment. Its knockdown enhances paclitaxel sensitivity by suppressing proliferation, migration, invasion, angiogenesis and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0005785 functions as a miR-640 sponge to regulate GSK3beta expression. |
| Confidence score: |
0.7951 |