| Expression pattern: |
UP |
| Associated gene: |
TRIM41, p53 |
| Associated microRNA: |
- |
| Biological function: |
Promotes paclitaxel chemoresistance of NPC cells, promotes proliferation, migration and invasion under paclitaxel treatment, and decreases paclitaxel-mediated apoptosis. |
| Molecular mechanism: |
circRNA_0067717 acts as a scaffold for TRIM41 and p53, enhances TRIM41-mediated p53 ubiquitination and degradation, decreases p53 protein levels, and thereby induces paclitaxel chemoresistance. |
| Biological pathway or process: |
drug resistance (promotes); chemoresistance (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); ubiquitination (promotes); p53 signaling (inhibits) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; FISH / smFISH; IF (Immunofluorescence); Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circRNA_0067717 may serve as a potential therapeutic target for NPC and targeting the circRNA_0067717-TRIM41-p53 complex may be a new therapeutic strategy for paclitaxel resistance in NPC. |
| Description: |
hsa_circ_0067717/circRNA_0067717 is upregulated in paclitaxel-resistant NPC cell lines. It promotes paclitaxel chemoresistance by acting as a scaffold that brings TRIM41 and p53 together, enhancing TRIM41-mediated ubiquitination and degradation of p53. Blocking the TRIM41 or p53 binding regions on circRNA_0067717 restores p53 stability and increases paclitaxel sensitivity. |
| Confidence score: |
0.852 |