| Expression pattern: |
UP |
| Associated gene: |
PGK1, phosphoglycerate kinase 1, AGO2, Bax, MMP2 |
| Associated microRNA: |
miR-411-5p |
| Biological function: |
Circ_0076305 promotes PCa cell growth, DNA synthesis, migration, glycolysis and tumour growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0076305 acts as a ceRNA by sponging miR-411-5p to upregulate PGK1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Circ_0076305 can discriminate PCa tissues from normal tissues with an AUC value of 0.9049 and may be a diagnostic and prognostic biomarker for PCa treatment. |
| Description: |
Circ_0076305 is up-regulated in prostate cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-411-5p to increase PGK1 expression, thereby promoting proliferation, migration, glycolysis and xenograft tumour growth while inhibiting apoptosis. Its expression showed diagnostic potential for distinguishing PCa tissues from normal tissues. |
| Confidence score: |
0.8201 |