| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Biomarker for predicting immunotherapy response in NSCLC. |
| Molecular mechanism: |
Not specified; used in Lasso model to predict response. |
| Biological pathway or process: |
drug resistance (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; ROC Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
Predicts immunotherapy response in NSCLC; included in a Lasso model with AUC 0.812 and validated by qPCR. |
| Description: |
In NSCLC immunotherapy cohorts, EV-derived circTBC1D22A is higher in responders and serves as a liquid-biopsy biomarker for response prediction; it is also combined with circNFATC2 in a Lasso classifier with AUC ~0.81. |
| Confidence score: |
0.5047 |