| Expression pattern: |
UP |
| Associated gene: |
MAPK1, Ago2 |
| Associated microRNA: |
miR-490-3p |
| Biological function: |
promotes proliferation, migration, and invasion of NSCLC cells |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-490-3p to enhance MAPK1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes); MAPK (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_101237 expression predicted poor survival in NSCLC; associated with lymph node metastasis, large tumor size and advantaged TNM stage |
| Description: |
hsa_circ_101237 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC cell proliferation, migration and invasion by acting as a ceRNA that sponges miR-490-3p, thereby increasing MAPK1 expression, and high expression is associated with poorer patient survival. |
| Confidence score: |
0.8323 |