circRNA basic information
circBase ID: hsa_circ_0000348
Name: hsa_circ_FAT3
Synonym: circ_0000348
Host Gene: FAT3
Genomic location(hg19): chr11:92085261-92088570:+
Genomic location(hg38): chr11:92352095-92355404:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005306
MONDO name: ankylosing spondylitis
Disease details: ankylosing spondylitis / AS
Disease DO ID:
 7147
Disease MeSH ID:
 D013167
Disease NCIt ID:
 C84564
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FAT3
Associated microRNA: miR-133b
Biological function: unknown
Molecular mechanism: Predicted interaction with miR-133b in a TGF-beta signaling pathway-related circRNA-miRNA network.
Biological pathway or process:

TGF-beta/SMAD (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Transfection; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0000348 (from FAT3) is up-regulated in osteogenically differentiated AS-BMSCs. Although predicted to interact with miR-133b in a TGF-beta-related network, its knockdown did not noticeably change mineralization in HD- or AS-BMSCs in this study.
Confidence score:

0.695
Other information
Title:

RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.

Journal: Frontiers in genetics
Published: 2022
PubMed ID: 35873481
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fgene.2022.947120/full#supplementary-material
Code availability: -