| Expression pattern: |
UP |
| Associated gene: |
API5 |
| Associated microRNA: |
miR-197-3p |
| Biological function: |
Promotes GBM cell proliferation, invasion, tumor growth and radioresistance; inhibits apoptosis and radiosensitivity. |
| Molecular mechanism: |
circ_0060055 acts as a miR-197-3p sponge to regulate API5 expression, thereby promoting GBM progression and radioresistance. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); radioresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Sanger Sequencing; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0060055 might be a potential target for treating GBM and improving radiosensitivity. |
| Description: |
circ_0060055 is up-regulated in GBM tumor tissues and cells. It promotes GBM proliferation, invasion, tumor growth, and radioresistance while suppressing apoptosis, mainly by sponging miR-197-3p to positively regulate API5. The study suggests circ_0060055 as a potential therapeutic target for GBM and radiosensitization. |
| Confidence score: |
0.8443 |