| Expression pattern: |
UP |
| Associated gene: |
AR-V9, AR-FL, AR-V3, AR-V7 |
| Associated microRNA: |
- |
| Biological function: |
Potential coding peptide (hypothesized) and biomarker relevance in castration-resistant progression. |
| Molecular mechanism: |
Transcriptional regulation (correlates with AR transcripts); possible peptide-coding potential (hypothesis). |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
H
S
|
| Validation methods: |
divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
RISH signals stronger in castration-resistant PDXs; part of circAR set proposed as circulating biomarkers. |
| Description: |
circAR-E3 is an AR-derived circRNA significantly upregulated in castration-resistant PDX tumors and predominantly localized in the cytoplasm, validated by fractionation and BaseScope RISH. It is discussed as part of a circAR biomarker set for mCRPC, and it has hypothesized peptide-coding potential based on an open reading frame. |
| Confidence score: |
0.7008 |