circRNA basic information
circBase ID: hsa_circ_0072309
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr5:38523520-38530768:-
Genomic location(hg38): chr5:38523418-38530666:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

AGS; MKN-45; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PPARgamma, PTEN, PI3K, AKT, mTOR
Associated microRNA: -
Biological function: inhibits proliferation; inhibits migration; inhibits invasion
Molecular mechanism: Activates PPARgamma/PTEN signaling and suppresses PI3K/AKT signaling (reduced phosphorylation of PI3K/AKT/mTOR) in gastric cancer cells.
Biological pathway or process:

PI3K/AKT (inhibits); PI3K/AKT/mTOR (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot
Clinical significance:

-
Description:

hsa_circ_0072309 is down-regulated in gastric cancer cell lines. Its overexpression suppresses gastric cancer cell proliferation, migration and invasion by activating PPARgamma/PTEN signaling and inhibiting PI3K/AKT/mTOR phosphorylation.
Confidence score:

0.4236
Other information
Title:

Circular RNA hsa_circ_0072309 inhibits the proliferation, invasion and migration of gastric cancer cells via inhibition of PI3K/AKT signaling by activating PPARgamma/PTEN signaling.

Journal: Molecular medicine reports
Published: 2021
PubMed ID: 33760104
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -