| Expression pattern: |
UP |
| Associated gene: |
OCIAD2 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
promotes LUAD cell migration, proliferation, and sphere-forming ability; promotes xenograft tumor growth |
| Molecular mechanism: |
acts as a miR-145-5p sponge to increase OCIAD2 expression (ceRNA mechanism) |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); stemness (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; EdU Staining; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
could be a useful target for the diagnosis and treatment of LUAD |
| Description: |
hsa_circ_0001492 is up-regulated in LUAD tissues/cells and mainly localizes to the cytoplasm. It promotes LUAD proliferation, migration, invasion and sphere formation by sponging miR-145-5p to de-repress OCIAD2, and its silencing inhibits xenograft tumor growth. |
| Confidence score: |
0.8439 |