| Expression pattern: |
UP |
| Associated gene: |
AGO2 |
| Associated microRNA: |
miR-23a |
| Biological function: |
promotes cell proliferation, colony formation, invasion, and tumor growth in prostate cancer |
| Molecular mechanism: |
ceRNA sponging of miR-23a; negatively regulates miR-23a expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); metastasis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining |
| Clinical significance: |
circXPO1 may serve as a biomarker for prostate cancer; potential therapeutic target |
| Description: |
circXPO1 is up-regulated in prostate cancer tissues and cell lines and predominantly localized in the cytoplasm. It promotes prostate cancer cell proliferation/colony formation and invasion in vitro and tumor growth in a PC-3 xenograft model by sponging miR-23a and suppressing miR-23a levels. |
| Confidence score: |
0.7629 |