| Expression pattern: |
UP |
| Associated gene: |
SOX4, beta-catenin, cyclin D1, c-myc, Ago2 |
| Associated microRNA: |
miR-503 |
| Biological function: |
CircSAMD11 promotes cervical cancer cell proliferation, migration, invasion and tumorigenesis, and inhibits apoptosis. |
| Molecular mechanism: |
CircSAMD11 acts as a cytoplasmic ceRNA that sponges miR-503 to up-regulate SOX4 expression and activate the Wnt/beta-catenin pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circSAMD11 expression was closely related to poor overall survival and circSAMD11 was proposed as a promising therapeutic target for cervical cancer. |
| Description: |
hsa_circ_0009189/circSAMD11 is up-regulated in cervical cancer tissues and cells and high expression is associated with poor overall survival. Functionally, circSAMD11 promotes proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circSAMD11 sponges miR-503 to increase SOX4 expression and activate the Wnt/beta-catenin pathway. |
| Confidence score: |
0.8793 |