| Expression pattern: |
UP |
| Associated gene: |
ROCK2 |
| Associated microRNA: |
miR-622 |
| Biological function: |
circ_0000467 functions as an oncogenic regulator in gastric cancer; its inhibition suppresses GC cell proliferation, migration, invasion, and tumor growth, and induces apoptosis. |
| Molecular mechanism: |
circ_0000467 acts as a sponge for miR-622 to upregulate ROCK2 expression through a ceRNA mechanism. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0000467 might be a novel diagnostic marker for GC. |
| Description: |
circ_0000467 is up-regulated in gastric cancer tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, and tumor growth while inhibiting apoptosis by sponging miR-622 and increasing ROCK2 expression. The study suggests circ_0000467 may have diagnostic or therapeutic relevance in GC. |
| Confidence score: |
0.8298 |