circRNA basic information
circBase ID: hsa_circ_0005526
Name: hsa_circ_RUNX2
Synonym: circ_RUNX2
Host Gene: RUNX2
Genomic location(hg19): chr6:45459677-45460699:+
Genomic location(hg38): chr6:45491940-45492962:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005178
MONDO name: osteoarthritis
Disease details: osteoarthritis
Disease DO ID:
 8398
Disease MeSH ID:
 D010003
Disease NCIt ID:
 C3293
Disease ICD11 ID:
 558562409
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

C-28/I2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: COL1A1, TNC, LAMB2, COL4A2, COL6A2, DAG1, SDC4, COL6A1, THBS1, COL1A2, COL3A1
Associated microRNA: miR-498, miR-924, miR-361-3p, miR-665
Biological function: May be involved in OA development and act as a miRNA sponge to regulate miRNA expression.
Molecular mechanism: circ_RUNX2 acts as a miRNA sponge (miR-498/miR-924/miR-361-3p/miR-665) and is linked by bioinformatics to ECM-receptor interaction targets (e.g., COL1A1, TNC).
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; Bioinformatics Analysis; Clinical Sample Validation; ROC Analysis
Clinical significance:

Serum circ_RUNX2 shows potential diagnostic value for OA (AUC 0.82, sensitivity 0.78, specificity 0.77).
Description:

hsa_circ_0005526 (circ_RUNX2), derived from RUNX2, is up-regulated in OA patient serum and is mainly cytoplasmic in cartilage cells. It sponges miR-498/miR-924/miR-361-3p/miR-665 and is linked to the ECM-receptor interaction pathway; serum circ_RUNX2 shows diagnostic potential for OA (AUC 0.82).
Confidence score:

0.7241
Other information
Title:

The role of circRNA derived from RUNX2 in the serum of osteoarthritis and its clinical value.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 34165827
Study type:

combined biological and clinical study
Data availability: The datasets during and/or analyzed during the current study available from the corresponding author on reasonable request.
Code availability: -