| Expression pattern: |
UP |
| Associated gene: |
AR-FL, AR-V3, AR-V7, AR-V9 |
| Associated microRNA: |
- |
| Biological function: |
Associated with castration-resistant progression; potential circulating marker of AR/AR-variant expression. |
| Molecular mechanism: |
Transcriptional mechanism: circAR level changes mirror AR-FL and AR-V levels; androgen suppresses expression and antiandrogen attenuates suppression. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
S
|
| Validation methods: |
divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
Potential circulating biomarker for castration-resistant progression (general circAR statement). |
| Description: |
circAR-E2In2 is upregulated in castration-resistant PDX tumors and its expression tracks with linear AR/AR-variant transcription, consistent with transcriptional regulation rather than a global increase in circRNA formation. It is predominantly cytoplasmic and is discussed as part of an AR-circRNA set with potential biomarker value in mCRPC. |
| Confidence score: |
0.695 |