| Expression pattern: |
UP |
| Associated gene: |
AR-FL, AR-V3, AR-V7, AR-V9 |
| Associated microRNA: |
- |
| Biological function: |
May serve as a surrogate circulating marker for AR/AR-variant expression and castration-resistant prostate cancer progression. |
| Molecular mechanism: |
Transcriptional regulation linked to AR gene transcription; expression correlates with linear AR transcripts. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
S
|
| Validation methods: |
divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
May serve as surrogate circulating markers for AR-V expression and mCRPC progression; detectable in plasma. |
| Description: |
circAR-E2In1 is an AR-derived circRNA upregulated during castration-resistant progression in LuCaP PDX models and correlated with linear AR/AR-variant expression in mCRPC samples. It localizes predominantly to the cytoplasm and is proposed as a potential circulating biomarker reflecting AR transcriptional output. |
| Confidence score: |
0.7008 |