| Expression pattern: |
UP |
| Associated gene: |
YTHDF2, STAT5A |
| Associated microRNA: |
miR-1238 |
| Biological function: |
promote proliferation, migration, and invasion of colorectal cancer cells; promote CRC progression/metastasis |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-1238, increasing YTHDF2 expression; associated with decreased STAT5A methylation via YTHDF2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes); m6A modification (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; RIP (RNA Immunoprecipitation) |
| Clinical significance: |
- |
| Description: |
circSKA3 is up-regulated in colorectal cancer tissues and promotes malignant phenotypes (proliferation, migration, invasion) in CRC cells. Mechanistically, circSKA3 acts as a ceRNA to sponge miR-1238, thereby increasing YTHDF2 expression and linking to reduced STAT5A methylation. |
| Confidence score: |
0.7032 |