| Expression pattern: |
UP |
| Associated gene: |
LASP1, DOCK1 |
| Associated microRNA: |
miR-494-3p |
| Biological function: |
promotes cisplatin resistance, proliferation and invasion; inhibits apoptosis in DDP-resistant ESCC cells |
| Molecular mechanism: |
circ_0007142 acts as a miRNA sponge for miR-494-3p to upregulate LASP1 |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Circ_0007142 is highly expressed in DDP-resistant ESCC tissues compared with DDP-sensitive ESCC tissues. |
| Description: |
hsa_circ_0007142 (circ_0007142) is upregulated in cisplatin-resistant ESCC tissues and DDP-resistant cell models. Functionally, it promotes cisplatin resistance, proliferation and invasion while suppressing apoptosis by sponging miR-494-3p to increase LASP1 expression, and its knockdown enhances DDP sensitivity in vitro and in a xenograft model. |
| Confidence score: |
0.7859 |