circRNA basic information
circBase ID: hsa_circ_0008549
Name: hsa_circ_OSBPL10
Synonym: circRNA oxysterol binding protein like 10 / cir-c_OSBPL10
Host Gene: OSBPL10
Genomic location(hg19): chr3:31917924-31921322:-
Genomic location(hg38): chr3:31876432-31879830:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma / OSCC
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tissues; normal oral cavity tissues; primary tumor tissues
Cell lines:

CAL-27; SCC-9; HOK; 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CDK6
Associated microRNA: miR-299-3p
Biological function: Circ_OSBPL10 promotes OSCC cell proliferation, cell cycle progression, colony formation, migration, invasion and tumor growth, and inhibits apoptosis; silencing circ_OSBPL10 suppresses these malignant behaviors and diminishes tumor growth in vivo.
Molecular mechanism: Circ_OSBPL10 functions as a competing endogenous RNA for miR-299-3p to regulate CDK6 expression, thereby affecting OSCC cell functional behaviors.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model
Clinical significance:

circ_OSBPL10 is highlighted as a promising therapeutic target for OSCC.
Description:

circ_OSBPL10 is up-regulated in OSCC tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, colony formation, migration, invasion and in vivo tumor growth while suppressing apoptosis, at least partly through the circ_OSBPL10/miR-299-3p/CDK6 ceRNA axis. The study proposes circ_OSBPL10 inhibition as a potential therapeutic strategy for OSCC.
Confidence score:

0.7183
Other information
Title:

Silencing of circ_OSBPL10 affects the functional behaviors of oral squamous cell carcinoma cells by the miR-299-3p/CDK6 axis.

Journal: Archives of oral biology
Published: 2022
PubMed ID: 35180547
Study type:

combined biological and clinical study
Data availability: GSE118750; doi:10.1016/j.archoralbio.2022.105363
Code availability: -