circRNA basic information
circBase ID: -
Name: hsa_circ_ARHGAP26
Synonym: ARHGAP26-11281-A5BS
Host Gene: ARHGAP26
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer's disease / AD
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BM44 brain region; BM22 brain region
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-140-5p
Biological function: may release miR-140-5p and enhance miR-140-5p activity when down-regulated in AD brain regions
Molecular mechanism: Predicted miRNA sponging/release mechanism: downregulation reduces soaking, releasing miR-140-5p and enhancing its activity (supported by decreased expression of miR-140-5p targets)
Biological pathway or process:

ceRNA regulation (inhibits); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

In AD cortex regions, ARHGAP26-11281-A5BS is down-regulated and is predicted to sponge miR-140-5p under normal conditions. Its depletion in AD is associated with release of miR-140-5p and increased miR-140-5p activity, reflected by reduced expression of miR-140-5p target genes.
Confidence score:

0.1768
Other information
Title:

Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer's disease using circMeta2.

Journal: Communications biology
Published: 2024
PubMed ID: 39427093
Study type:

bioinformatics study
Data availability: ENCODE database (Experiment IDs in Supplementary Data 1); Synapse SynID: syn3159438; Supplementary Data 4
Code availability: https://github.com/lichen-lab/circMeta2