| Expression pattern: |
UP |
| Associated gene: |
HOXB7, AGO2 |
| Associated microRNA: |
miR-889-3p |
| Biological function: |
promotes cell proliferation, migration, invasion and radioresistance; inhibits apoptosis; reduces radiosensitivity; promotes tumor growth |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0009035 binds miR-889-3p and modulates HOXB7 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); radioresistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
associated with the radioresistance of CC patients; potential clinical significance as a diagnostic biomarker |
| Description: |
hsa_circ_0009035 is up-regulated in cervical cancer tissues/cells and is linked to radioresistance. Functionally, it promotes proliferation, migration and invasion while inhibiting apoptosis, enhancing tumor growth and reducing radiosensitivity. Mechanistically, it acts as a ceRNA by sponging miR-889-3p to increase HOXB7 expression. |
| Confidence score: |
0.8738 |