| Expression pattern: |
UP |
| Associated gene: |
PRMT3, PRMT3 mRNA |
| Associated microRNA: |
miR-194-5p |
| Biological function: |
Promotes HCC cell proliferation, invasion, and migration, and inhibits apoptosis; knockdown reduces HCC cell activity. |
| Molecular mechanism: |
circERBB3 acts as a ceRNA that competitively binds miR-194-5p to upregulate PRMT3 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
CircERBB3 may be used as a prognostic biomarker or therapeutic target for HCC. |
| Description: |
This study identifies circERBB3 as an oncogenic circRNA in HCC cell lines. circERBB3 is upregulated in Huh7 and HepG2 cells and promotes proliferation, invasion, migration, and apoptosis resistance by competitively binding miR-194-5p and thereby increasing PRMT3 expression. |
| Confidence score: |
0.5627 |