circRNA basic information
circBase ID: hsa_circ_0018905
Name: hsa_circ_SAMD8
Synonym: -
Host Gene: SAMD8
Genomic location(hg19): chr10:76910271-76928416:+
Genomic location(hg38): chr10:75150513-75168658:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005301
MONDO name: multiple sclerosis
Disease details: multiple sclerosis / MS
Disease DO ID:
 2377
Disease MeSH ID:
 D009103
Disease NCIt ID:
 C3243
Disease ICD11 ID:
 1298865187
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PBMCs
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: IKZF3, SMAD8
Associated microRNA: miRNA-6727-3p
Biological function: Candidate MS blood biomarker; decreased expression is associated with higher disability and progressive forms of MS.
Molecular mechanism: Predicted ceRNA mechanism: binds miRNA-6727-3p and potentially affects IKZF3 expression.
Biological pathway or process:

ceRNA regulation (other); immune regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Downregulated in MS PBMCs; further decreased in higher disability and progressive MS; high diagnostic performance by ROC (AUC 0.948).
Description:

hsa_circ_0018905 is down-regulated in MS PBMCs and shows further reduction with greater disability and progressive MS forms. It has strong diagnostic potential by ROC analysis and is predicted to participate in a ceRNA axis involving miRNA-6727-3p and IKZF3.
Confidence score:

0.5963
Other information
Title:

Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.

Journal: Cells
Published: 2024
PubMed ID: 39404430
Study type:

combined biological and clinical study
Data availability: All data needed to evaluate the conclusions in the paper are present in the paper and in the Supplementary Materials.
Code availability: -