circRNA basic information
circBase ID: hsa_circ_0000511
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: RPPH1
Genomic location(hg19): chr14:20811282-20811431:-
Genomic location(hg38): chr14:20343123-20343272:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005301
MONDO name: multiple sclerosis
Disease details: multiple sclerosis / MS
Disease DO ID:
 2377
Disease MeSH ID:
 D009103
Disease NCIt ID:
 C3243
Disease ICD11 ID:
 1298865187
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PBMCs; serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RREB1, HuR
Associated microRNA: -
Biological function: Upregulated in MS PBMCs and detectable in serum; expression decreases with higher disability (EDSS) in RRMS and SPMS. Proposed biomarker relevance and potential contribution to demyelination via HuR sequestration.
Molecular mechanism: Predicted involvement in circRNA-miRNA-mRNA networks (RREB1) and possible RBP (HuR) sequestration.
Biological pathway or process:

ceRNA regulation (other); immune regulation (other); inflammation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Validated upregulated in MS PBMCs; also validated in serum. Lower levels are associated with higher disability (EDSS>4.5) in RRMS and SPMS.
Description:

hsa_circ_0000511 is up-regulated in MS PBMCs versus controls and is also validated in serum. Its PBMC level is lower in more disabled RRMS/SPMS patients (higher EDSS), suggesting association with disease severity and involvement in regulatory networks including RREB1 and RBP sequestration (HuR).
Confidence score:

0.5135
Other information
Title:

Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.

Journal: Cells
Published: 2024
PubMed ID: 39404430
Study type:

combined biological and clinical study
Data availability: All data needed to evaluate the conclusions in the paper are present in the paper and in the Supplementary Materials.
Code availability: -