| Expression pattern: |
DN |
| Associated gene: |
IGFBP2, NRAS, SRSF1, VEGFA |
| Associated microRNA: |
miR-126-3p, miR-515-5p |
| Biological function: |
tumor suppressor; regulates downstream miRNAs and inhibits expression of oncogenic targets in GBM context |
| Molecular mechanism: |
Upstream regulation of miRNA expression (miR-126-3p, miR-515-5p) with downstream repression of targets (IGFBP2, NRAS); previously shown decoy for RBP SRSF1 affecting splicing |
| Biological pathway or process: |
ceRNA regulation (other); angiogenesis (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circSMARCA5 has been described as a good diagnostic candidate biomarker of GBM (serum-derived EVs). |
| Description: |
In glioblastoma, circSMARCA5 is down-regulated and functions as a tumor suppressor. It acts as an upstream regulator increasing miR-126-3p and miR-515-5p, which are associated with reduced expression of their oncogenic mRNA targets IGFBP2 and NRAS, and is also linked to RBP (SRSF1) decoy/splicing-related regulation. |
| Confidence score: |
0.4535 |