circRNA basic information
circBase ID: hsa_circ_0000517
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: RPPH1
Genomic location(hg19): chr14:20811404-20811492:-
Genomic location(hg38): chr14:20343245-20343333:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005301
MONDO name: multiple sclerosis
Disease details: multiple sclerosis / MS
Disease DO ID:
 2377
Disease MeSH ID:
 D009103
Disease NCIt ID:
 C3243
Disease ICD11 ID:
 1298865187
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PBMCs
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RREB1, PLEC
Associated microRNA: miR-326
Biological function: Potential MS biomarker candidate; predicted to sponge miRNAs (e.g., miR-326) and influence MS-associated gene regulatory networks.
Molecular mechanism: Predicted ceRNA regulation via circRNA-miRNA-mRNA networks (in silico).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Upregulated in PBMCs of MS patients versus healthy controls (validated by RT-qPCR).
Description:

hsa_circ_0000517 is up-regulated in PBMCs from MS patients and is predicted to act within a ceRNA network, potentially sponging miR-326 and affecting MS-associated gene regulation.
Confidence score:

0.5135
Other information
Title:

Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.

Journal: Cells
Published: 2024
PubMed ID: 39404430
Study type:

combined biological and clinical study
Data availability: All data needed to evaluate the conclusions in the paper are present in the paper and in the Supplementary Materials.
Code availability: -