| Expression pattern: |
UP |
| Associated gene: |
interleukin 7, insulin-like growth factor binding protein 1, transcription factor E2F7, MAPK signaling pathway, Ubiquitin mediated proteolysis, TGF-beta signaling pathway |
| Associated microRNA: |
miR-216a-3p, miR-302a-3p, miR-892a, miR-493-5p, miR-200c-5p |
| Biological function: |
Potential involvement in NSCLC tumorigenesis, progression and metastasis; potential biomarker for NSCLC diagnosis. |
| Molecular mechanism: |
Predicted to act as a miRNA sponge forming a circRNA-miRNA-mRNA network (Top-5 miRNAs; 333 target genes) based on TargetScan/miRanda predictions. |
| Biological pathway or process: |
ceRNA regulation (other); MAPK (other); TGF-beta/SMAD (other); ubiquitination (other); proliferation (other); invasion (other); metastasis (other); migration (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Diagnostic potential (AUC 0.878); high expression associated with TNM stage and lymphatic metastasis. |
| Description: |
hsa_circ_0014130 is significantly up-regulated in NSCLC tissues and is associated with higher TNM stage and lymphatic metastasis. It shows diagnostic potential (AUC 0.878) and is predicted to act via a ceRNA-like circRNA-miRNA-mRNA network involving miR-216a-3p, miR-302a-3p, miR-892a, miR-493-5p and miR-200c-5p, with enriched pathways including MAPK and TGF-beta signaling and ubiquitin-mediated proteolysis. |
| Confidence score: |
0.6841 |