| Expression pattern: |
UP |
| Associated gene: |
RREB1, PLEC, HuR, FUS |
| Associated microRNA: |
miR-326 |
| Biological function: |
Potential non-invasive biomarker candidate for MS; may act as a miRNA sponge and potentially sequester RBPs (e.g., HuR), contributing to immune dysregulation and demyelination-related processes. |
| Molecular mechanism: |
Predicted ceRNA network (circRNA sponging miRNAs) affecting MS-associated genes; predicted RBP binding/sequestration. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other); inflammation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Candidate blood/serum circRNA biomarker for MS (validated upregulation in PBMCs; also detectable and increased in serum). |
| Description: |
hsa_circ_0000518 is up-regulated in PBMCs of MS (RRMS) patients versus healthy controls and was also detected as increased in serum. The study further predicts it participates in circRNA-miRNA-mRNA and circRNA-RBP regulatory networks relevant to MS-associated genes. |
| Confidence score: |
0.5135 |