circRNA basic information
circBase ID: hsa_circ_0009910
Name: hsa_circ_MFN2
Synonym: circ_0009910 / circ-0009910
Host Gene: MFN2
Genomic location(hg19): chr1:12049221-12052747:+
Genomic location(hg38): chr1:11989164-11992690:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential oncogenic role; associated with HCC progression and metastasis risk (biomarker-related evidence).
Molecular mechanism: Not functionally validated in this study; biomarker association only.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Diagnostic and prognostic plasma biomarker for HCC; correlates with tumor size, metastasis, AFP levels, stage and cirrhosis; AUC = 0.90 for distinguishing HCC from controls.
Description:

Plasma circ_0009910 is significantly up-regulated in HCC patients and shows strong diagnostic performance versus healthy controls. Its higher levels are associated with more aggressive clinicopathological features (larger tumor size, advanced stage, metastasis, higher AFP), supporting its use as a non-invasive diagnostic/prognostic biomarker, though functional mechanisms were not experimentally validated.
Confidence score:

0.559
Other information
Title:

Preliminary Evaluation of Plasma circ_0009910, circ_0027478, and miR-1236-3p as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma.

Journal: International journal of molecular sciences
Published: 2025
PubMed ID: 40429981
Study type:

combined biological and clinical study
Data availability: GSE94508; GSE97332
Code availability: -