| Expression pattern: |
DN |
| Associated gene: |
FTO |
| Associated microRNA: |
- |
| Biological function: |
Inhibits proliferation, migration, invasion, and tumorigenesis in OSCC (tumour suppressor). |
| Molecular mechanism: |
Binds FTO protein, prevents its degradation and increases FTO protein stability, reducing overall m6A methylation levels. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); m6A modification (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; Transfection; CCK8; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); ROC Analysis; Bioinformatics Analysis; Actinomycin D / DRB Stability Assay |
| Clinical significance: |
ROC curve analysis suggested circGDI2 is diagnostically meaningful for OSCC; circGDI2 expression correlated with OSCC differentiation grade. |
| Description: |
circGDI2 is down-regulated in OSCC tissues and cell lines and acts as a tumour suppressor. It directly binds the FTO protein, stabilizes it against degradation, reduces cellular m6A methylation, and thereby inhibits OSCC cell proliferation, migration, invasion and xenograft tumorigenesis. |
| Confidence score: |
0.8682 |