| Expression pattern: |
UP |
| Associated gene: |
CANX, Ago2, PD-L1, TGFB1, p-SMAD2 |
| Associated microRNA: |
miR-505-3p |
| Biological function: |
promotes proliferation; promotes immune evasion; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0007991 sponges miR-505-3p to regulate CANX expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); immune regulation (inhibits); TGF-beta/SMAD (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; ELISA; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNase R Treatment; Actinomycin D / DRB Stability Assay; Bioinformatics Analysis |
| Clinical significance: |
increased levels correlating with advanced TNM stages |
| Description: |
hsa_circ_0007991 is up-regulated in HCC tissues/cell lines and promotes tumor cell proliferation and immune evasion while inhibiting apoptosis. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-505-3p to increase CANX expression, impacting PD-L1 and TGF-beta/SMAD-related immunosuppressive signaling in co-culture assays with CD8+ T cells. |
| Confidence score: |
0.8237 |