| Expression pattern: |
UP |
| Associated gene: |
FGFR1 |
| Associated microRNA: |
miR-637 |
| Biological function: |
Circ_SNX27 promotes HCC cell proliferation, migration, invasion, and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_SNX27 acts as a ceRNA/sponge for miR-637 to promote FGFR1 expression, thereby contributing to HCC development. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Colony Formation Assay; EdU Staining; MTT; Western Blot; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Targeting the circ_SNX27/miR-637/FGFR1 axis may be a potential therapeutic approach for HCC. |
| Description: |
Circ_SNX27 is up-regulated in human HCC tissues and cell lines and mainly localizes to the cytoplasm. It functions as an oncogenic circRNA by promoting proliferation, migration, invasion, EMT-related marker changes, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_SNX27 sponges miR-637 to increase FGFR1 expression, forming a circ_SNX27/miR-637/FGFR1 regulatory axis. |
| Confidence score: |
0.8175 |