circRNA basic information
circBase ID: -
Name: hsa_circ_LARP4
Synonym: circＲNA La-associated protein 4 / circ_LAＲP4
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Overexpression of circ_LAＲP4 inhibits proliferation, invasion, migration-associated ability, and stem cell-like characteristics of MCF-7 breast cancer cells, and reduces iNOS and IL-1beta secretion.
Molecular mechanism: circ_LAＲP4 overexpression down-regulates ki67, OCT4, SOX2, VEGF, N-cadherin, iNOS and IL-1beta, and up-regulates p21 and E-cadherin, thereby suppressing proliferation, stemness, invasion/EMT-related behavior, angiogenesis-related protein expression and inflammatory cytokine production.
Biological pathway or process:

proliferation (inhibits); invasion (inhibits); migration (inhibits); stemness (inhibits); EMT (inhibits); inflammation (inhibits); angiogenesis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Transwell Assay; Western Blot; ELISA
Clinical significance:

-
Description:

This study investigated circ_LAＲP4 in MCF-7 human breast cancer cells using an overexpression model. circ_LAＲP4 overexpression inhibited proliferation, invasion/migration-related behavior and stem cell-like characteristics, while reducing iNOS and IL-1beta levels. Mechanistically, the study links these effects to altered expression of ki67, p21, OCT4, SOX2, VEGF, N-cadherin and E-cadherin.
Confidence score:

0.421
Other information
Title:

[Overexpression of circ_LARP4 inhibits the proliferation and migration of MCF-7 human breast cancer cells and its mechanism].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Published: 2022
PubMed ID: 35365990
Study type:

biological research
Data availability: -
Code availability: -