| Expression pattern: |
UP |
| Associated gene: |
RAP1B, ERK1/2, AKT |
| Associated microRNA: |
miR-188-3p |
| Biological function: |
circ_0078607 promotes gastric cancer cell proliferation, cell cycle progression and tumor growth, and inhibits apoptosis; silencing circ_0078607 prevents proliferation, arrests cells in G1 phase, induces apoptosis and inhibits tumor growth in vivo. |
| Molecular mechanism: |
circ_0078607 acts through a ceRNA-like miR-188-3p/RAP1B axis and activates ERK1/2/AKT signaling; knockdown of circ_0078607 increases miR-188-3p, decreases RAP1B, and inhibits phosphorylation of ERK1/2 and AKT. |
| Biological pathway or process: |
ERK (promotes); PI3K/AKT (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
circ_0078607 might serve as a potential tumor promoter in gastric cancer; the study suggests potential value for diagnosis, treatment, prediction and prognosis, but no direct survival or diagnostic performance analysis was reported. |
| Description: |
circ_0078607 is up-regulated in gastric cancer tissues, patient plasma and gastric cancer cell lines. It functions as a tumor-promoting circRNA by regulating the miR-188-3p/RAP1B axis and ERK1/2/AKT signaling, thereby promoting proliferation and tumor growth while suppressing apoptosis. |
| Confidence score: |
0.7289 |