| Expression pattern: |
UP |
| Associated gene: |
YWHAZ |
| Associated microRNA: |
hsa-miR-22-3p |
| Biological function: |
promotes HCC proliferation, migration and metastasis; promotes autophagy; promotes HCC growth in vivo |
| Molecular mechanism: |
ceRNA/miRNA sponge: hsa_circ_0016662 sponges hsa-miR-22-3p to regulate YWHAZ, involving autophagy in HCC progression |
| Biological pathway or process: |
autophagy (promotes); proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Bioinformatics Analysis; Clinical Sample Validation; Cohort Study |
| Clinical significance: |
prognostic biomarker in HCC; upregulated in HCC tissues |
| Description: |
hsa_circ_0016662 is upregulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes HCC proliferation, migration and metastasis by sponging hsa-miR-22-3p to regulate YWHAZ, with autophagy contributing to the malignant phenotype. |
| Confidence score: |
0.7738 |