circRNA basic information
circBase ID: hsa_circ_0004365
Name: hsa_circ_SEMA3C
Synonym: hsa_circRNA_104421
Host Gene: SEMA3C
Genomic location(hg19): chr7:80418621-80440017:-
Genomic location(hg38): chr7:80789305-80810701:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0019954
MONDO name: pancreatic neuroendocrine tumor
Disease details: pancreatic neuroendocrine tumors / pNETs
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C27720
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary carcinoma tumor tissue; liver metastasis; tissues adjacent to cancer
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: potential biomarker for pNET tumorigenesis and metastasis
Molecular mechanism: ceRNA network (bioinformatics-predicted) with enrichment in integrin-mediated cell adhesion regulation and other pathways
Biological pathway or process:

ceRNA regulation (other); apoptosis (other); immune regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

potential biomarker for pNET tumorigenesis and metastasis
Description:

hsa_circ_0004365 (from SEMA3C) is significantly upregulated from adjacent tissue to primary pNET and further to liver metastasis in patient samples. The study builds a predicted ceRNA network for hsa_circ_0004365 and reports pathway enrichments (including apoptosis and NK cell-mediated cytotoxicity), supporting its potential as a biomarker for pNET tumorigenesis and metastasis.
Confidence score:

0.5135
Other information
Title:

Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors.

Journal: Biochemistry and biophysics reports
Published: 2025
PubMed ID: 40007573
Study type:

combined biological and clinical study
Data availability: GSE73338; https://doi.org/10.1016/j.bbrep.2025.101935
Code availability: -