circRNA basic information
circBase ID: hsa_circ_0015756
Name: -
Synonym: circ_0015756
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; matched adjacent normal tissues; cancerous liver tissues; noncancerous liver tissues
Cell lines:

WRL-68; MHCC97H; MHCC-97H; Bel-7402; Huh-7; Huh7; Bel-100; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FAK, Akt, Snail-1, Slug, MMP-9
Associated microRNA: miR-7
Biological function: circ_0015756 promotes HCC cell proliferation, viability, migration, invasion, tumor growth and intrahepatic metastasis, and inhibits apoptosis.
Molecular mechanism: circ_0015756 functions as a miR-7 sponge to upregulate FAK expression and promote the Akt pathway, with downstream effects on Snail-1, Slug and MMP-9.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); EMT (promotes); PI3K/AKT (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model; H&E Staining
Clinical significance:

Modulation of circ_0015756, miR-7 and FAK levels exhibits a promise in the treatment of HCC.
Description:

circ_0015756 is up-regulated in HCC tissues and cell lines. Functionally, it promotes HCC proliferation, migration, invasion, tumor growth and intrahepatic metastasis while suppressing apoptosis. Mechanistically, circ_0015756 sponges miR-7 to relieve repression of FAK and activate the Akt-related pro-metastatic program involving Snail-1, Slug and MMP-9.
Confidence score:

0.6544
Other information
Title:

Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma.

Journal: Cell cycle (Georgetown, Tex.)
Published: 2019
PubMed ID: 31522588
Study type:

combined biological and clinical study
Data availability: -
Code availability: -