| Expression pattern: |
UP |
| Associated gene: |
ZNF268 |
| Associated microRNA: |
miR-567 |
| Biological function: |
Promotes proliferation, colony formation, migration and invasion; inhibits apoptosis in cervical cancer cells. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-567 to enhance ZNF268 expression (ceRNA-like regulation). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
High hsa_circ_000543 expression indicated shorter survival time and predicted poor prognosis in CC patients; associated with FIGO stage and tumor size. |
| Description: |
In cervical cancer, hsa_circ_000543 is up-regulated and acts as an oncogenic circRNA. It sponges miR-567 to increase ZNF268 expression, thereby promoting proliferation/colony formation/migration/invasion and inhibiting apoptosis; high expression is associated with poorer overall survival. |
| Confidence score: |
0.7657 |