| Expression pattern: |
UP |
| Associated gene: |
IGF2, AGO2 |
| Associated microRNA: |
miR-218-5p |
| Biological function: |
Promotes gastric cancer cell proliferation and tumor growth; knockdown suppresses proliferation. |
| Molecular mechanism: |
Acts as a miR-218-5p sponge to regulate IGF2 expression, thereby affecting gastric cancer cell proliferation. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; In Vivo Animal Model |
| Clinical significance: |
High circRNA_100,349 expression predicts poor prognosis and shows prospective clinical value as a tumor biomarker (ROC AUC = 0.9594). |
| Description: |
circRNA_100349 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with poor overall survival and diagnostic value. Functionally, circRNA_100349 promotes gastric cancer proliferation and tumor growth by sponging miR-218-5p to increase IGF2 expression; its knockdown suppresses proliferation in vitro and xenograft growth in vivo. |
| Confidence score: |
0.7969 |