| Expression pattern: |
UP |
| Associated gene: |
MMP2 |
| Associated microRNA: |
miR-145 |
| Biological function: |
promotes proliferation, migration and invasion and inhibits apoptosis of SCLC cells |
| Molecular mechanism: |
circMYC acts as a ceRNA to sponge miR-145, thereby upregulating MMP2 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circMYC expression is associated with a poor prognosis in SCLC patients. |
| Description: |
circMYC is up-regulated in SCLC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, circMYC is mainly cytoplasmic and acts as a ceRNA that sponges miR-145 to de-repress MMP2, forming a circMYC/miR-145/MMP2 axis associated with poor prognosis. |
| Confidence score: |
0.817 |