| Expression pattern: |
UP |
| Associated gene: |
FOXK1, beta-catenin, c-myc, cyclinD1, Wnt/beta-catenin signaling pathway |
| Associated microRNA: |
miR-186 |
| Biological function: |
Promotes lung adenocarcinoma cell proliferation, migration, invasion and metastasis, and inhibits apoptosis; high expression is associated with advanced TNM stage, lymphatic and distant metastases, and shorter overall survival. |
| Molecular mechanism: |
circ_0007142 functions as a miR-186 sponge, regulates the miR-186/FOXK1 axis, and activates the Wnt/beta-catenin signaling pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
Increased circ_0007142 expression was associated with TNM stage, lymphatic and distant metastases; high circ_0007142 expression predicted significantly shorter overall survival. |
| Description: |
circ_0007142 is up-regulated in lung adenocarcinoma tissues and cell lines and is associated with advanced disease features and poor overall survival. Functionally, circ_0007142 promotes proliferation, migration, invasion and metastasis and suppresses apoptosis. Mechanistically, it acts through the miR-186/FOXK1 axis to activate the Wnt/beta-catenin signaling pathway. |
| Confidence score: |
0.7631 |