| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-361-3p |
| Biological function: |
promotes proliferation; promotes invasion; promotes epithelial-mesenchymal transition (EMT) |
| Molecular mechanism: |
Acts as a miRNA sponge binding miR-361-3p; miR-361-3p suppression rescues phenotypes caused by circ-MYBL2 knockdown. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot |
| Clinical significance: |
High circ-MYBL2 expression was associated with advanced FIGO stage, larger tumor size, lymph node metastasis, and poor prognosis in CC patients. |
| Description: |
circ-MYBL2 (hsa_circ_0060467) is up-regulated in cervical cancer and promotes malignant phenotypes (proliferation, invasion, EMT). Mechanistically, it functions as a sponge for miR-361-3p, and miR-361-3p inhibition rescues the effects of circ-MYBL2 knockdown. High circ-MYBL2 expression is associated with advanced clinical features and poor prognosis. |
| Confidence score: |
0.7537 |