circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: CDR1-AS
Host Gene: CDR1
Genomic location(hg19): chrX:139865339-139866824:+
Genomic location(hg38): chrX:140783174-140784659:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary cancer tissue specimens / BC tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Associated with neoadjuvant chemotherapy response (pCR) and patient survival outcomes (DFS, RFS, DDFS) in locally advanced breast cancer.
Molecular mechanism: Not investigated in this study (clinical biomarker-focused); prior mechanistic studies are discussed but not experimentally tested here.
Biological pathway or process:

chemoresistance (other); drug resistance (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

CDR1-AS expression is an independent predictive factor for pCR after NAC, and an independent prognostic factor for DFS, RFS, and DDFS in locally advanced breast cancer.
Description:

In a prospective Chinese cohort of locally advanced breast cancer treated with paclitaxel-cisplatin neoadjuvant chemotherapy, CDR1-AS expression in pretreatment tumor tissue was associated with treatment response and prognosis. Lower CDR1-AS expression predicted higher pCR rates, while higher CDR1-AS expression was associated with better DFS/RFS/DDFS; no mechanism was experimentally established in this work.
Confidence score:

0.5339
Other information
Title:

Value of CDR1-AS as a predictive and prognostic biomarker for patients with breast cancer receiving neoadjuvant chemotherapy in a prospective Chinese cohort.

Journal: European journal of medical research
Published: 2024
PubMed ID: 39261936
Study type:

combined biological and clinical study
Data availability: The datasets reported in the current study are available from the corresponding author upon reasonable request.
Code availability: -