circRNA basic information
circBase ID: -
Name: mmu_circ_RERE
Synonym: circ:chr4:150406196-150406664 (circRERE-PMN)
Host Gene: RERE
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0024883
MONDO name: metastatic neoplasm
Disease details: pre-metastatic niche
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C3261
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

lung tissues; pre-metastatic lung tissue; liver; kidney
Cell lines:

MLE-12; B16F10
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HUR
Associated microRNA: -
Biological function: inhibits apoptosis; promotes expression of cytokines and chemokines in alveolar epithelial cells
Molecular mechanism: Potential interaction with RNA-binding protein HUR to regulate apoptosis and inflammatory cytokine/chemokine expression
Biological pathway or process:

apoptosis (inhibits); inflammation (promotes); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; FISH / smFISH; IF (Immunofluorescence); Transfection; CCK8; Annexin V/PI Flow Cytometry; Bioinformatics Analysis; In Vivo Animal Model; H&E Staining
Clinical significance:

-
Description:

circRERE-PMN is up-regulated in mouse pre-metastatic lung tissue and is enriched in MDSCs, macrophages, and especially alveolar epithelial cells, mainly in the cytoplasm. In alveolar epithelial cells, circRERE-PMN inhibits apoptosis and promotes expression of PMN-associated cytokines/chemokines (e.g., S100A8/A9, CXCL1/2, Bv8, MMP9), potentially via interaction with the RBP HUR.
Confidence score:

0.5307
Other information
Title:

CircRNAs expression profile and potential roles of circRERE-PMN in pre-metastatic lungs.

Journal: Frontiers in immunology
Published: 2024
PubMed ID: 39253079
Study type:

combined biological and bioinformatics study
Data availability: GSE274656
Code availability: -