circRNA basic information
circBase ID: hsa_circ_0001329
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr3:119219541-119222868:+
Genomic location(hg38): chr3:119500694-119504021:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005081
MONDO name: preeclampsia
Disease details: preeclampsia / PE
Disease DO ID:
 10591
Disease MeSH ID:
 D011225
Disease NCIt ID:
 C85021
Disease ICD11 ID:
 229121159
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

placental tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: MAP1LC3B
Associated microRNA: hsa-miR-760
Biological function: May participate in PE as a ceRNA by capturing hsa-miR-760 and being linked to MAP1LC3B regulation.
Molecular mechanism: ceRNA mechanism involving hsa-miR-760/MAP1LC3B axis
Biological pathway or process:

ceRNA regulation (other); autophagy (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; ROC Analysis
Clinical significance:

ROC analysis indicated relatively high diagnostic value, with AUC of hsa_circ_0001329 of 0.75.
Description:

hsa_circ_0001329 was down-regulated in PE placental tissue and was validated by RT-qPCR and GEO dataset analysis. The authors proposed that it may participate in PE through a ceRNA mechanism involving hsa-miR-760 and MAP1LC3B, and ROC analysis suggested potential diagnostic value.
Confidence score:

0.5047
Other information
Title:

Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia.

Journal: Placenta
Published: 2022
PubMed ID: 35121166
Study type:

combined bioinformatics and clinical study
Data availability: GSE102897; GSE96984; GSE10588; GSE84260; GSE165324; Supplementary data: https://doi.org/10.1016/j.placenta.2022.01.013
Code availability: -