| Expression pattern: |
UP |
| Associated gene: |
ARG1, AGO2 |
| Associated microRNA: |
MIR4521 |
| Biological function: |
promotes diabetes-induced vascular endothelial dysfunction, decreases NO content and ENOS activity, increases ROS and adhesion molecules, impairs vasodilation |
| Molecular mechanism: |
circHMGCS1 acts as a miRNA sponge for MIR4521, thereby upregulating ARG1 and driving endothelial dysfunction (reduced NO/ENOS activity, increased ROS and adhesion molecules). |
| Biological pathway or process: |
ceRNA regulation (promotes); apoptosis (not specified); proliferation (promotes); inflammation (promotes); oxidative phosphorylation (not specified); migration (not specified); invasion (not specified); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circHMGCS1 is up-regulated in diabetes-associated endothelial dysfunction models and promotes vascular endothelial dysfunction. It functions as a cytoplasmic ceRNA that sponges MIR4521, thereby increasing ARG1 expression, reducing NO production and ENOS activity, and enhancing ROS generation and adhesion molecule expression in vitro and in HFHG diet-induced diabetic mice. |
| Confidence score: |
0.8166 |