circRNA basic information
circBase ID: hsa_circ_0029325
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr12:125270902-125284788:-
Genomic location(hg38): chr12:124786356-124800242:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; HCC tissue; peritumoral tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Argonaute2 (AGO2)
Associated microRNA: -
Biological function: associated with poor prognosis and higher recurrence rates after curative resection in HCC
Molecular mechanism: unknown
Biological pathway or process:

not specified
Detected method:
Q
H
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

High exosomal hsa_circ_0029325 is an independent risk factor for poor prognosis and predicts OS and RFS after radical resection in HCC; incorporated into nomograms with good predictive performance.
Description:

Exosomal hsa_circ_0029325 is up-regulated in HCC (plasma and tissue-derived exosomes) and higher expression is associated with higher recurrence and worse overall survival after curative resection. It serves as an independent prognostic factor and improves prediction performance when incorporated into OS/RFS nomograms; its molecular mechanism was not experimentally resolved in this study.
Confidence score:

0.6677
Other information
Title:

Nomograms incorporating hsa_circ_0029325 highly expressed in exosomes of hepatocellular carcinoma predict the postoperative outcomes.

Journal: Discover oncology
Published: 2024
PubMed ID: 38836972
Study type:

combined biological and clinical study
Data availability: available from the corresponding author upon reasonable request
Code availability: -