circRNA basic information
circBase ID: -
Name: hsa_circ_LPAR1
Synonym: circLPAR1(2,3)
Host Gene: LPAR1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adenoma tissue; adjacent non-malignant mucosa
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Associated with widespread circRNA downregulation possibly linked to host gene transcription and RBP-mediated biogenesis; no specific mechanism experimentally demonstrated for circLPAR1(2,3) in this study.
Biological pathway or process:

proliferation (inhibits); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ddPCR
Clinical significance:

Lower levels of circLPAR1(2,3) were significantly associated with better overall survival.
Description:

circLPAR1(2,3) is down-regulated in colorectal tumor and adenoma tissues versus matched adjacent mucosa. Lower circLPAR1(2,3) levels are associated with better overall survival in CRC patients in this cohort.
Confidence score:

0.3872
Other information
Title:

Multiple regulatory events contribute to a widespread circular RNA downregulation in precancer and early stage of colorectal cancer development.

Journal: Biomarker research
Published: 2025
PubMed ID: 39980011
Study type:

combined biological and clinical study
Data availability: GSE233799; GSE156451; GSE142279; GSE95132; GSE74602; GSE41657; GSE20916; GSE8671; GSE77953; GSE4183; TMECircDB/GSE221240; GSE132465
Code availability: -