| Expression pattern: |
UP |
| Associated gene: |
GATA6, IL-6, IL-1beta, TNF-alpha |
| Associated microRNA: |
miR-144-3p |
| Biological function: |
Acts as an exercise-responsive circulating biomarker and modulates inflammatory signaling in airway epithelial cells. |
| Molecular mechanism: |
circTSN functions as a cytoplasmic miRNA sponge for miR-144-3p to relieve repression of GATA6, thereby modulating inflammatory gene expression. |
| Biological pathway or process: |
inflammation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; Transfection; Bioinformatics Analysis; Clinical Sample Validation; In Vivo Animal Model; Cohort Study |
| Clinical significance: |
circTSN is an exercise-responsive circulating RNA negatively associated with systemic inflammation and may serve as a systemic biomarker during pulmonary rehabilitation in COPD. |
| Description: |
In COPD rehabilitation, circTSN increases after exercise training and is inversely associated with systemic inflammatory markers. It localizes mainly in the cytoplasm and acts as a ceRNA by sponging miR-144-3p to de-repress GATA6, thereby modulating inflammatory gene expression in airway epithelial cells and supporting its utility as a systemic biomarker of exercise-induced adaptation. |
| Confidence score: |
0.7693 |